Which of the following statements is NOT true regarding carboxyhemoglobin (HbCO)?

The assertion that HbCO dissociates with difficulty accurately reflects the nature of carbon monoxide's interaction with hemoglobin. When carbon monoxide binds to hemoglobin, it does so with a much greater affinity than oxygen—approximately 200 to 250 times stronger. This strong binding means that once CO is attached to hemoglobin, it does not release easily, leading to a state where hemoglobin is effectively less able to transport oxygen.

Consequently, the presence of carboxyhemoglobin in the bloodstream significantly hinders the release of oxygen to tissues because the binding of CO prevents hemoglobin from engaging with oxygen effectively. Thus, an increased concentration of HbCO can significantly impair oxygen delivery, compounding the hypoxic conditions in tissues that need oxygen for cellular metabolism.

Understanding the properties of carboxyhemoglobin, including its affinity and the difficulty of dissociating from hemoglobin, is crucial for recognizing the potential clinical ramifications of carbon monoxide exposure in patients.