Is pancreatic blood flow effectively autoregulated during hypothermic CPB?

Pancreatic blood flow is not effectively autoregulated during hypothermic cardiopulmonary bypass (CPB). Autoregulation refers to the ability of an organ to maintain a constant blood flow despite changes in perfusion pressure. During hypothermic CPB, various physiological changes occur that can disrupt normal autoregulation mechanisms, including altered metabolic requirements and increased vascular resistance.

In the case of low temperatures, the vasoconstrictive response may be impaired, leading to unpredictable changes in blood flow. This is particularly important in the pancreas, as it is sensitive to ischemic conditions and can suffer from inadequate blood supply during periods of altered hemodynamics, such as those seen during CPB.

Although different populations (like adults and neonates) might exhibit variations in how their organs respond to changes in blood flow during CPB, the overarching principle remains that, in the context of hypothermic conditions, pancreatic blood flow does not exhibit effective autoregulation. Thus, the assertion that the statement is false is correct.