True or False: Renal impairment likely influences heparin longevity.

Renal impairment does indeed influence the longevity of heparin in the body. Heparin is mainly cleared from the bloodstream by the reticuloendothelial system, with a fraction undergoing renal clearance, particularly low molecular weight heparins (LMWH). In individuals with renal impairment, the ability of the kidneys to excrete these drugs is diminished, leading to prolonged effects of heparin.

In patients with compromised renal function, the half-life of heparin can be extended, which increases the risk for bleeding complications and necessitates careful monitoring of anticoagulation levels. This clinical understanding emphasizes that adjustments in dosage may be required in patients with renal impairment to maintain therapeutic efficacy while minimizing the risk of adverse effects. This correlation between renal function and the pharmacokinetics of heparin is well-documented, making the statement that renal impairment likely influences heparin longevity accurate.